Professor Dr. Melvin George

Professor Dr. Melvin George

Head of the Department

Govt funded projects as PI:

  • Phase 3 Dengue vaccine trial
  • Acute coronary syndrome prognostic biomarkers
  • Indian Cardiovascular Research Advocacy Group 2 -ICMR CAR project- regional centre (PI)
  • Epigenetic aging & CAD

Other major projects as the investigator

  • TIPS-3 polypill study – phase 3 clinical trial for polypill in patients with high cardiovascular risk (2014-2020)
  • ODYSSEY Outcomes study –phase 3 clinical trial on Alirocumab in post-acute coronary syndrome (2014-2018)
  • ACT study – clinical trial for Colchicine in COVID infection (2020-2022)
  • Phase 1 & phase 2 clinical trial for Covaxin- inactivated whole cell Virion vaccine in healthy volunteers - BBIL (2020-2021)
  • Phase 3 clinical trial for Covaxin- inactivated whole cell Virion vaccine in healthy volunteers BBIL- (2020-2022)
  • Phase 3 clinical trial for COVID vaccine by Sanofi-GSK (2021-2022)
  • Indian COPD Registry (2022-2024)
  • Heart Failure Registry (2022-204)
  • UNISUS study - Phase 3 clinical trial on macitentan in pulmonary arterial hypertension (2023- 2025)

Significant achievements

Recognized as Nodal Officer, ICMR Centre for Clinical Trials at SRM Medical College through ICMR

INTENT Network

  • Total number of publications: 85
  • H-index: 21
  • i-10 index – 34
  • Total number of citations: 1284
  • Total number of regulatory trials as investigator: 18
  • Total number of academic studies as investigator: 53
  • Number of guest lectures delivered: 110
  • Number of clinical research training workshops organized: 22

Key Responsibilities

  • General Secretary, Association of Clinical Pharmacologists of India
  • Treasurer, Medical Pharmacologists Society
  • Chairperson, Gleneagles Hospital IEC, Chennai
  • Chairperson, Chettinad Medical College, Chennai
  • Member Secretary, SRM MCH Ethics Committee, Chennai
  • Member, Pushpagiri Medical College IRB, Kerala
  • Member, Tambaram IMA Ethics Committee, Chennai
  • Member, Indian Society of Clinical Research
  • Member, National Association of Pharmacology & Therapeutics
  • Member, Forum for Ethics Review Committees in India


  • Goenka L, George M, Selvarajan S. End points in heart failure-are we doing it right? Eur J Clin Pharmacol. 2017 Jun;73(6):651-659.
  • Goenka L, George M, Sen M. A peek into the drug development scenario of endometriosis - A systematic review. Biomed Pharmacother. 2017 Jun;90:575-585.
  • Paul AA, Dkhar SA, Kamalanathan S, Thabah MM, George M, Chandrasekaran I, Gunaseelan V, Selvarajan S. Effect of metformin on exercise capacity in metabolic syndrome. Diabetes Metab Syndr. 2017 Nov;11 Suppl 1:S403-S406.
  • Goenka L, George M, Singh V, Jena A, Seshadri D, Karunakaran V, Elumalai DV, Rani J, Kaliappan I. Do ANGPTL-4 and galectin-3 reflect the severity of coronary artery disease? Ther Adv Cardiovasc Dis. 2017 Oct;11(10):261-270.
  • Jha D, Goenka L, Ramamoorthy T, Sharma M, Dhandapani VE, George M. Prognostic role of soluble ST2 in acute coronary syndrome with diabetes. Eur J Clin Invest. 2018 Sep;48(9)
  • Goenka L, Uppugunduri Satyanarayana CR, S SK, George M. Neuroprotective agents in Acute Ischemic Stroke-A Reality Check. Biomed Pharmacother. 2019.
  • George M, Goenka L. Alirocumab in Post ACS Patients - Saving Lives at a Premium. Curr Cardiol Rev. 2022;18(1)
  • Raj JP, Venkatachalam S, Amaravati RS, et al. Extent of awareness and attitudes on plagiarism among post-graduate resident doctors and junior medical faculty in India: a cross-sectional, multicentric study. BMJ Open. 2021;11(6):e046904. Published 2021 Jun 16.
  • Raj V, Charles S, Goenka L, et al. Assessment of Peripheral Blood Mononuclear Cells Senescence and Endothelial Dysfunction among Adults with High Cardiovascular Risk. Arq Bras Cardiol. 2021;116(1):37-47.
  • Selvarajan S, Anandaradje A, Shivabasappa S, Melepurakkal Sadanandan D, Nair NS, George M. Efficacy of pharmacological interventions in COVID-19: A network meta-analysis. Br J Clin Pharmacol. 2022;88(9):4080-4091.
  • Raj JP, Venkatachalam S, Amaravati RS, et al. Extent of knowledge and attitudes on plagiarism among undergraduate medical students in South India - a multicentre, cross-sectional study to determine the need for incorporating research ethics in medical undergraduate curriculum. BMC Med Educ. 2022;22(1):380. Published 2022 May 18.
  • Idhrees M, Narayan P, George M, Radhakrishna P, Abraham SJ, Velayudhan B. The motivators and barriers to a career in cardiothoracic surgery: a cross-sectional study among surgical residents in India. Indian J Thorac Cardiovasc Surg. 2022;38(6):613-623.
  • Kaushik RR, Koranne M, Rao MS, Rakshit S, Shanmugam G, George M, Sarkar K, Role of Diospyros peregrina fruit preparation in suppressing regulatory T (Treg) cells in the tumor microenvironment of breast and lung cancer, Phytomedicine Plus, Volume 2, Issue 4, 2022.
  • Rathinam KK, Abraham JJ, S HP, S A S, Sen M, George M, A P. Evaluation of pharmacological interventions in the management of adenomyosis: a systematic review. Eur J Clin Pharmacol. 2022 Apr;78(4):531-545.
  • Rathinam KK, Abraham JJ, Karuppaiah H, Selvaraj HP, Samal S, George M. Evaluation of Endpoints Used in Clinical Trials on Adenomyosis - A Systematic Review. Rev Recent Clin Trials. 2023;18(2):83-91.
  • George M, Balachandran K, Jinson J. Fathoming the Role of Semaglutide in Obesity Therapeutics. Clin Ther. 2023;45(8):804-805.
  • Samal S, Manoharan K, Jinson J, George M, Rao AA. Prediction of maternal and fetal outcomes among patients with preeclampsia using circulatory biomarkers (MMP-9 & ST2) - A prospective cohort study. Placenta. 2023;142:12-17.
  • Manoharan K; Jinson J; Ramesh K; George M. Clinical trial trends over the last 5 years among the BRICS (Brazil, Russia, India, China, and South Africa) nations. Perspectives in Clinical Research. October 27, 2023.