About Us
- SRM Centre for Clinical Pharmacology is a dedicated research facility spanning 4500sq.ft with its focus on generating evidence for systematic evaluation of drugs, devices, and vaccines. The Centre has been involved in conducting several investigator-initiated studies, regulatory clinical trials, nationwide disease registries, and translational clinical research studies. Our facility has expertise in executing projects from its genesis to publication.
- The Centre is mainly involved in Clinical Research that performs sponsored Multi-centric Clinical Trials, Academic Clinical trials, and Principal Investigator-initiated Academic studies. At present, the Centre has one professor, one clinical research manager, one lecturer, two clinical research associates, one clinical research coordinator, one scientist, one scientific writer, one research administrative assistant, and three clinical pharmacists.
- The Centre has facilities to perform phase 3& phase /4 clinical trials including data documentation using electronic case report form or paper case report form, dedicated space for storing Investigational Medicinal Products, and Archival room for storage of documents of clinical trials that have been completed, Audio-Visual consenting room, Phlebotomy room, Data Monitoring Room, Board Room, Library, Seminar room, Document storage room, patient examination room, high-speed internet, power back up, -80 deep freezer, Ultra cooling centrifuge, refrigerator, Hot water bath, Autoclave, Incubator with shaker, ELISA washer, and reader and a clinical pharmacology lab for performing laboratory assays. The department was established in October 2012.
Quick Access
Our Vision
- To be a centre of excellence engaged in designing & executing high-quality multicentric research relevant to the healthcare needs of the global community.
- To network with leading institutions in evidence-based medicine and generate reliable data that change clinical practice
- To develop leaders who can make a significant impact in drug development research.
Our Mission
- To instill knowledge of the fundamentals of clinical research and foster skills required in day-to-day research.
- To advocate and make best research practices the norm to ensure that every research team provides robust and reliable data.
- To cultivate ethical & moral values and provide ample opportunities for budding researchers.
Academics
It is a postgraduate course conducted by Centre for Clinical Pharmacology, SRM Medical College Hospital & Research Centre
Duration of the course: 2 years
About the course
The M.Sc. Clinical Research degree program is designed to enable the candidate to excel as a Clinical Research Professional in the pharmaceutical industry, Contract Research Organizations, and hospitals.
The course is structured such that a candidate has a solid foundation in the basic medical sciences, followed by intensive training in regulations, ethics, clinical trial operations, clinical pharmacology, pharmacovigilance, data management, medical writing & biostatistics.
The candidate will gain hands-on experience in the various nuances concerning clinical trials in the hospital, biostatistics & scientific writing.
Eligibility: B. Tech Biotechnology, B. Sc Microbiology, B.Sc. Biochemistry, B.Pharm, B.Sc. Statistics, MBBS, BDS, B.Sc. Allied Health Science, B.Sc. Nursing
- BSc Biochemistry.
- BSc Microbiology.
- B. Tech Biotechnology.
- B. Pharm.
- B.Sc. Nursing.
- B.Sc. Statistics.
- MBBS.
- BDS.
- Any BSc Allied Health Sciences
- B.Sc. Biotechnology
- B.Sc. Medical Biotechnology
- B.Tech Biomedical Engineering
- B.Sc. Biomedical Science
- B.Sc. Bioinformatics/Health informatics/Data Science
- BSc. Clinical Research
Program Fees: ₹ 2, 00, 000
Curriculum
Semester 1
Anatomy & Physiology, Pathology, Pharmacology, Laboratory Medicine & Disease Management, Clinical Pharmacology, Communication Skills
Semester 2
Basics of Clinical Research, Drug Discovery & Drug Development, Regulations & Ethics in Clinical Research, Clinical Trial Operations, Devices/Vaccines/Oncology Drug Development, Personality Development
Semester 3
Pharmacovigilance& Data Management, Publication & Scientific writing, Applied Biostatistics, Real World Evidence & Systematic Review / Meta-Analysis, Soft Skills Development/Career Guidance & Interview Preparation
Semester 4
Dissertation work and Internship
For Registration: https://applications.srmist.edu.in/hspg
It is an offline training program conducted by the Centre for Clinical Pharmacology, SRM Medical College Hospital & Research Centre.
Duration of Course: 3-6 months
Timings: Monday to Friday (09:00 AM-05:00 PM)
Content of Course
- Clinical Research Methodology
- Good Clinical Research Practice
- Biostatistics & Data Management
- Scientific Writing
- Scientific Presentations
Benefits of the Course
The candidate will be provided with an internship certificate after training and will be better poised to work in clinical research settings in the academics and industry. The candidate will obtain hands-on training by being part of the team that is managing the clinical research projects.
Who can apply?
Masters/Bachelors in Life sciences which includes biotechnology, genetic engineering, pharmacy, and biomedical engineering.
Selection of candidates will be based on interviews. Interested candidates can send their CVs to: melving@srmist.edu.in
Program fee: INR – 4000/month; 12000 for 3 months; 24000 for 6 months
This is a unique B-School style certificate course aimed at imparting knowledge on business-critical aspects of drug development, pharmacovigilance, and medical affairs along with the practice of essential soft skills that lie at the core of the pharmaceutical industry. In addition, the course also focuses on the various career paths and how to plan your career path in the pharmaceutical industry.
Course Highlights:
- 8-month course including webinars and onsite module.
- 50 webinars (1 to 2 webinars per week), ~4 virtual case studies, team-based project work
- 5 days of the onsite module cover hands-on sessions, interactions with industry experts, and career path discussion.
- Access to P2PC alumni - Learn from Alumni through dedicated sessions.
- Top performers to be awarded with special mentorship programs.
- Potential internship opportunities for top performers
Eligibility: MD Pharmacology & DM Clinical Pharmacology pursuing students and pass-outs.
| Registration Start | May |
| Registration End | July |
| Exam date | July |
| Results date | July |
| Final date for payment | July |
| Start of the webinar | July |
Fee:
- INR 500/- for registrations and screening tests.
- INR 50,000/- for the full course (Includes webinars, onsite module costs for the venue, food, faculty charges, and material)
For details or questions, please contact:
Prof. Dr. Melvin George / Ms. Kaviya Manoharan
Ph: 044-47432564; 044-27455826
Email: melving@srmist.edu.in/kaviyam@srmist.edu.in/ cpd.mhs@srmist.edu.in
Infrastructure
The SRM Centre for Clinical Pharmacology is a pinnacle of modern infrastructure constructed specifically for advanced research with furnished air-conditioned rooms for work-space and storage. Every space is utilized efficiently, balcony space is utilized for trial studies like a 6-minute walk test.
Investigational Product storage room
Equipped with temperature-controlled storage units, 24/7 air-conditioned access controlled; and monitoring systems.
Document Storage Room
Access to the facility is restricted to authorized personnel only, Equipped with secure cabinets, shelves, and filing systems, the facility provides ample space to store a wide range of documents.
Data Monitoring Centre
End-to-end clinical trial site management including protocol development, data entry, data analysis, data interpretation, manuscript development, and publications. This sophisticated environment is also used for activities like site initiation, site visits, sponsor monitoring, and study audits. We perform Data Monitoring and Surveillance, Quality Control, Safety Monitoring, and Statistical Analysis.
Sample Processing and storage room
We are equipped with facilities that include a refrigerator, -80degree deep freezer, ultra cooling centrifuge, ELISA washer, ELISA reader, autoclave, an incubator with shaker, BP apparatus, hand grip dynamometer, Height scale & weight machine with temperature-controlled units set to optimal conditions for sample preservation.
AV Consent Room
Our AV Consent Room features multimedia presentations that explain key aspects of the research study in a clear and accessible manner.
Phlebotomy Room
We adhere to strict protocols for sterilization to meet stringent standards for infection control and patient safety during sample collection. The phlebotomy room is utilized for monitoring vitals, sample labeling, sample collection (whole blood serum plasma, urine samples, swabs), and sample documentation.
Board room
A versatile space designed to facilitate study-staff training, collaborative meetings, official hybrid meetings via (zoom, teams, and Google Meets), business meetings with national & international sponsors, and regulatory inspection for clinical trials.
Faculty
- IIISM
- Cardiology
- General Medicine
- Pediatrics
- Obstetrics & Gynecology
- Nephrology
- General surgery
- Pulmonary medicine
- Oncology
- Pharmacology
- Dermatology
- Biotechnology
- Orthopedics
- Indian Council of Medical Research (ICMR)
- Population Health Research Institute (PHRI, Canada)
- Labcorp
- Bharat Biotech
- Parexel
- Tablets (India) Limited
- Cipla
- Medidata
- Sanofi
- SignantHealth
- Godrej
- Janssen (Johnson & Johnson)
- Abiogenesis Clinpharm
- Scitus
- Cliantha Research
Research
| S.No | Project title | Collaborating department |
| 1 | A phase 3, Prospective, multicentre, double blinded, double-dummy, randomized, active controlled, parallel-group, group sequential, adaptive, event-driven study to compare efficacy, safety and tolerability of Macitentan 10mg in patients with pulmonary arterial hypertension, followed by an open- label treatment period with Macitentan 75mg. | Cardiology |
| 2 | The Clinical Presentation, Management and Outcomes of Heart Failure Patients in India – The Indian Heart Failure Registry (CURE-HF) study | Cardiology |
| 3 | The Clinical Presentation, Management and Outcomes among patients with Chronic Obstructive Pulmonary Disease – The Indian COPD Registry (INCOR) study | Respiratory medicine |
| 4 | Clinical profile and short-term outcomes of Acute Stroke in a Tertiary Care Hospital in South India | General Medicine |
| 5 | A Phase III, Multi-centre, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy,Immunogenicity and Safety of Single dose of Dengue Tetravalent Vaccine, Live Attenuated (Recombinant,Lyophilized) – “DengiAll” of Panacea Biotec Limited inHealthy Indian Adults. | Community Medicine, Microbiology |
| 6 | Efficacy of Astymin 3 as an add-on therapy to standard of care in reduction of hospitalization & improving wound healing in post-operative patients – A randomized, single blind, controlled clinical trial. | General Surgery & Obstetrics and Gynaecology |
| 7 | A randomized, double blind, placebo controlled, comparative study to evaluate the safety and anti-aging efficacy of orally administered herbal extract formulations in elderly healthy individuals | General Medicine, SRM Research Park |
| 8 | Utility of miRNA Biomarkers in patients with Acute Myocardial Infarction- A Prospective Pilot Study (UNIAMI Study) | Cardiology, Biotechnology |
| 9 | Evaluation of Epigenetic Aging and its Modulation by Beta-Nicotinamide Mononucleotide (Beta-NMN) in Patients Diagnosed with Coronary Artery Disease | Cardiology, SRM Research Park |
| 10 | Association between Matrix Metallo-Proteinases-9 (MMP-9) Gene Family Polymorphisms and Risk of Coronary Artery Disease: A Case Control Study | Cardiology |
| 11 | A multi-centre, Randomized, Double-Blind, Three-Arm, Placebo- Controlled, Parallel Design, Study to Evaluate the Efficacy and Safety of Ketoconazole2% Shampoo of EncubeEthicals Private Limited, India with Ketoconazole Shampoo, 2% of Padagis (Perrigo) Allegan, MI 49010 in Subjects with Tinea Versicolor. | Dermatology |
| 12 | Randomized, Multi-Centric, Comparative, Blinded, Parallel Group, Prospective Study, To Determine Clinical Efficacy and Safety of Theruptor Sterile Barrier Wound Dressing of CareNowI n Comparison WithBactigras of Smith & Nephew and Allevyn of Smith & Nephew on Wound Healing in Patients With Chronic Infected Wounds | General Surgery |
| S.No | Project title | Collaborating department |
| 1 | A Randomized Double Blind, Placebo-Controlled Parallel Group Study to evaluate the effect of Alirocumab (SAR236553/REGN727) on the Occurrence of Cardiovascular Events in patients who have recently experienced on Acute Coronary Syndrome- ODYSSEY OUTCOMES- (Sponsor phase 3 Clinical Trial) | Cardiology |
| 2 | A Randomized Double-Blind Placebo-controlled trial for the evaluation of a polycap, low dose aspirin and vitamin D supplementation in primary prevention.- the international polycap study 3 (TIPS-3)-(Sponsor phase 3 Clinical Trial) | Cardiology & General Medicine |
| 3 | The Association of Plasma Trimethylamine N-oxide in Indian Patients with Coronary Artery Disease with or without Type 2 Diabetes Melltus: A Prospective Cohort Study | Cardiology, Clinical nutrition |
| 4 | A randomized, double blind, three-arm, placebo controlled, parallel design, multi-center, clinical endpoint bioequivalence study of Ketoconazole shampoo 2% (test product) compared with Ketoconazole shampoo 2% (reference product) in adult subjects with Tinea Versicolor | Dermatology |
| 5 | Evaluation of smartphone based Artificial Intelligence (AI) - imaging system for screening of cervical cancer in female sex workers. | Gynecology |
| 6 | Prospective, Randomized, Active Controlled, Observer-blind Clinical Study Evaluating the Safety and Hemostat efficacy of Absorbable Hemostat Powder of Lucktin (Hainan) Biotech Co., Ltd., in comparison with AristaTM AH (Absorbable Hemostat) of Davol, Inc., Subsidiary of C. R. Bard, Inc. in Mild or Moderate Parenchymal or Soft Tissue Bleeding During General Surgery. | General Surgery |
| 7 | A double blinded randomized multicentric parallel group active controlled clinical trial comparing the efficacy of mupirocin ointment of apex laboratories pvt. ltd with mupirocin ointment (T-bact) of GSK, in the treatment of superficial primary bacterial skin infections. | Dermatology |
| 8 | Randomized, Multi-Centric, Comparative, Blinded, Parallel Group, Prospective Study, To Determine Clinical Efficacy and Safety OfTheruptor Surgical Wound Dressing of CareNow In Comparison With Tegaderm of 3M and Plain Gauze dressing on Wound Healing In Patients undergoing Abdominal and Joint surgeries. | General Surgery |
| 9 | A placebo controlled clinical trial to assess the efficacy and safety of Godrej’s (GOOD NIGHT) after-bite roll on in reducing mosquito bite induced erythema | Pediatrics |
| 10 | Prediction of maternal and foetal outcomes among patients with preeclampsia using circulatory biomarkers (MMP-9 & ST2) – A prospective cohort study | Obstetrics And Gynecology |
| 11 | ICMR-RUMC- A covid 19 study for the Assessment of Prophylaxis for Health care workers. | - |
| 12 | Role of Novel Renal Biomarkers in prognosticating patients with chronic kidney disease – A Prospective Cohort Study | Nephrology |
| 13 | Anti-Coronavirus Therapies to prevent progression of COVID-19 Trial (ACT) | General Medicine |
| 14 | An Event-Driven, Phase3, Randomized, Double-blind, Placebo-controlled, Multicentre Study to Evaluate the Efficacy, Safety, Immunogenicity, and Lot-to-Lot consistency of BBV152, a Whole virion Inactivated SARS-CoV-2 Vaccine in Adults≥18Years of Age. (COVAXIN Clinical Trial) | Community Medicine, General Medicine, CCTR |
| 15 | Evaluation of a multi-marker strategy to prognosticate patients with acute coronary syndrome | Cardiology |
| 15 | A Clinical Study to Evaluate the Efficacy and Safety of Femigard Gold In Uterine Disease Conditions And Menstrual Irregularities | Obstetrics And Gynecology |
| 16 | Identification of risk alleles associated Diabetes Kidney Disease (DKD) using the genotyping approaches | General Medicine & Nephrology |
| 17 | Comparative effectiveness of Cabergoline and Medroxyprogesterone acetate in the Treatment of Adenomyosis: A Randomized, Open-label, Parallel arm, Controlled clinical trial | Obstetrics And Gynecology |
| Publications | Year |
| George M, Amrutheshwar R, Rajkumar RP, Kattimani S, Dkhar SA. Newer antipsychotics and upcoming molecules for schizophrenia. Eur J Clin Pharmacol. 2013 Aug;69(8):1497-509. | 2013 |
| Selvarajan S, George M, Kumar SS, Dkhar SA. Clinical trials in India: Where do we stand globally? Perspect Clin Res. 2013 Jul;4(3):160-4. | |
| Sandhiya S, Melvin G, Kumar SS, Dkhar SA. The dawn of hedgehog inhibitors: Vismodegib. J Pharmacol Pharmacother. 2013 Jan;4(1):4-7. | |
| Selvarajan S, George M, Srinivasamurthy SK. Pharmacogenomics in Type 2 Diabetes Mellitus and Metabolic Disorders. In: Barh D, Dhawan D, Ganguly N, editors. Omics for Personalized Medicine. New Delhi: Springer; 2013.561-73 | |
| George M, Selvarajan S, Srinivasamurthy S K. Pharmacogenomics of Autoimmune Diseases. In: Barh D, Dhawan D, Ganguly N, editors. Omics for Personalized Medicine. New Delhi: Springer; 2013.249–62. | |
| George M, Rajaram M, Shanmugam E, VijayaKumar TM. Novel drug targets in clinical development for heart failure. Eur J Clin Pharmacol. 2014 Jul;70(7):765-74. | 2014 |
| Rajkumar RP, Melvin G. Pharmacovigilance for psychiatrists: An introduction. Indian J Psychiatry. 2014 Apr;56(2):176-81. | |
| Rajaram M, George M and Shanmugam E. Novel Therapeutic options for Familial Hypercholesterolaemia. Int J Pharm Sci Res. 2014;5(8):3304-11. | |
| Srivatsan V, George M, Shanmugam E. Utility of galectin-3 as a prognostic biomarker in heart failure: where do we stand? Eur J Prev Cardiol. 2015 Sep;22(9):1096-110. | |
| George M, Rajaram M, Shanmugam E. New and emerging drug molecules against obesity. J Cardiovasc Pharmacol Ther. 2014 Jan;19(1):65-76. | |
| George M, Selvarajan S. Clinical Trial Endpoints in Breast Cancer. In: Barh D, editor. Omics Approaches in Breast Cancer: Towards Next-Generation Diagnosis, Prognosis and Therapy. India: Springer; 2014. 535-45. | |
| Selvarajan S, George M, Kumar S. Non-invasive Nano diagnostics for Cancer. In: Barh | |
| D, Carpi A, Verma M, Gunduz M. Cancer Biomarkers: Non-invasive Early Diagnosis and Prognosis. CRC Press; 2014. | |
| Kola S, George M, Srinivasamurthy S, Selvarajan S, Tamilarasu K, Swaminathan R, Chandrasekaran A. Assessment of arterial stiffness index in hypertensive patients in relation to their treatment status attending a tertiary care center in South India. Pharmacol Pharm. 2014;5:413-8. | |
| Shanmugam E, Doss CR, George M, Jena A, Rajaram M, Ramaraj B, Anjaneyan K, Kanagesh B. Effect of tolvaptan on acute heart failure with hyponatremia--a randomized, double blind, controlled clinical trial. Indian Heart J. 2016 Apr;68 Suppl 1(Suppl 1):S15-21. | 2015 |
| George M, Ganesh MR, Sridhar A, Jena A, Rajaram M, Shanmugam E, Dhandapani VE. Evaluation of endothelial and platelet derived microparticles in patients with acute coronary syndrome. J Clin Diagn Res. 2015 Dec;9(12):OC09-13. | |
| Palaniappan M, Selvarajan S, George M, Subramaniyan G, Dkhar SA, Pillai AA, Jayaraman B, Chandrasekaran A. Pattern of adverse drug reactions reported with cardiovascular drugs in a tertiary care teaching hospital. J Clin Diagn Res. 2015 Nov;9(11):FC01-4. | |
| George M, Shanmugam E, Srivatsan V, Vasanth K, Ramraj B, Rajaram M, Jena A, Sridhar A, Chaudhury M, Kaliappan I. Value of pentraxin-3 and galectin-3 in acute coronary syndrome: a short-term prospective cohort study. Ther Adv Cardiovasc Dis. 2015 Oct;9(5):275-84. | |
| Sandhiya S, Dkhar SA, Pillai AA, George M, Jayaraman B, Chandrasekaran A. Comparison of ranolazine and trimetazidine on glycemic status in diabetic patients with coronary artery disease - a randomized controlled trial. J Clin Diagn Res. 2015 Jan;9(1):OC01-5. | |
| Munusamy V, George M, Jena A, Sridhar A Elumalai DV. Comparison of Visceral Adiposity Index with Other Indices of Adiposity in Patients with Acute Myocardial Infarction. PTB Reports. 2015;1(2):55-61 | |
| Shanmugam E, Jena A, George M. Riociguat: Something new in pulmonary hypertension therapeutics? J Pharmacol Pharmacother. 2015 Jan-Mar;6(1):3-6. | |
| George M, Selvarajan S, Muthukumar R, Elangovan S. Looking into the crystal ball-upcoming drugs for dyslipidemia. J Cardiovasc Pharmacol Ther. 2015 Jan;20(1):11-20. | |
| ArulJothi KN, Whitthall RA, Futema M, Humphries SE, George M, Elangovan S, Nair DR, Devi A. Molecular analysis of the LDLR gene in coronary artery disease patients from the Indian population. Clin Biochem. 2016 Jun;49(9):669-674. | 2016 |
| Uppugunduri CR, George M. Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition-The Dream of Translational Medicine. J Cardiovasc Pharmacol. 2016 Feb;67(2):191-2. | |
| George M, Jena A, Srivatsan V, Muthukumar R, Dhandapani VE. GDF 15-A Novel Biomarker in the Offing for Heart Failure. Curr Cardiol Rev. 2016;12(1):37-46. | |
| Suryadevara K, George M, Jena A, Dhandapani VE, Damodharan N, J J. Evaluation of soluble ST2 as a novel cardiovascular biomarker in patients with acute myocardial infarction. Int J Res Med Sci. 2016;4(12):5297–301. | |
| K S, George M, Seshadri D, Jena A, Chandraprabha N. Prevalence of anemia among health science students of a university in South India. Int J Res Med Sci. 2016;4(10):4598–601. | |
| George M, Jena A, Karthikeyan B.. Cangrelor - rising from the ashes: a phoenix story. Int J Basic Clin Pharmacol. 2016;5(1):225–8. | |
| Goenka L, George M, Karthikeyan B. Does periprocedural nicorandil improve cardiovascular outcomes in acute myocardial infarction? Meta-analysis. J Evid Based Med Health. 2016;3(97):5348-57. | |
| Sriram DK, Gowri G, Haridoss S, Venkatesan S, Rajendran I, George M. Association of galectin-3 with high cardiovascular risk in patients with type 2 diabetes attending a multi-specialty hospital in South India. Int J Res Med Sci. 2016;4(12):5417–21. | |
| Munusamy V, George M, Jena A, Sridhar AR. A retrospective study on the utility of GRACE and TIMI score to predict coronary revascularization among patients with acute coronary syndrome. 2016;15(10):1-7. p-ISSN: 2279-0861. | |
| Goenka L, George M, Selvarajan S. End points in heart failure-are we doing it right? Eur J Clin Pharmacol. 2017 Jun;73(6):651-9. | 2017 |
| Goenka L, George M, Sen M. A peek into the drug development scenario of endometriosis - A systematic review. Biomed Pharmacother. 2017 Jun;90:575-85. | |
| Paul AA, Dkhar SA, Kamalanathan S, Thabah MM, George M, Chandrasekaran I, Gunaseelan V, Selvarajan S. Effect of metformin on exercise capacity in metabolic syndrome. Diabetes Metab Syndr. 2017 Nov;11 Suppl1:S403-S406. | |
| Goenka L, George M, Singh V, Jena A, Seshadri D, Karunakaran V, Elumalai DV, Rani J, Kaliappan I. Do ANGPTL-4 and galectin-3 reflect the severity of coronary artery disease? Ther Adv Cardiovasc Dis. 2017 Oct;11(10):261-70. | |
| Goenka L, George M, Selvarajan S. Authors reply to "No, we are not-we keep forgetting the right ventricle". Eur J Clin Pharmacol. 2018 Jan;74(1):145-6. | |
| Prasanna S, Jena A, Dhandapani VE, George M. Does the Duration of DM & HbA1c Levels Influence the Onset of Diastolic Dysfunction? J Cardiovasc Med Surg. Volume 3December 2017. | |
| Nagarajan A, Abinaya M, Abirami S, George M, Elangovan S, Arikketh D. SCARB1 rs5888 c.1050C>T Polymorphism and the risk of hypercholesterolemia and myocardial infarction in Indian Tamil population. Pakistan Journal of Zoology. 2017;49:1019-24. | |
| Dua A, Shukla S, Uthra A, George M. Analysis and prediction of fatality due to heart disease. Jour of Adv Research in Dynamical & Control Systems. 2017;9:779-90. | |
| George M, Vickneshwaran V, Anandabaskar N, Satheesh S, Zachariah B, Selvarajan S, Jayaraman B, Chandransekaran A. Effect of nebivolol on endothelial dysfunction in coronary artery disease patients-an open label randomized controlled clinical trial (NEDCAD). J Cardiovasc Dis Res. 2017;8(2). | |
| Goenka L, Ray RS, Munnusamy V, Dhandapani V, George M. The prognostic value of ANGPTL-4 in acute coronary syndrome: A prospective cohort study. J Clin Diagn Res. 2018;12(11):FC01-FC04 | 2018 |
| Prabhu D, Madhu CR, George M, Jena A, Srivatsan V, Sridhar A, Dhandapani VE. Effect of ranolazine on improvement of left ventricular dysfunction in patients with chronic stable angina: a randomized controlled clinical trial. J Clin Prev Cardiol.2018;7(1):17-21. | |
| George M, Goenka L. Air Pollution and its association with cardiovascular diseases. J Cardiovas Med Surg. 2018;4:176-82. | |
| George M, Goenka L, Selvarajan S. Precision medicine in coronary artery disease. In: Barh | |
| D, editor. Precision Medicine in Cancers and Non-communicable diseases. CRC Press; 2018. 217-33. | |
| Jha D, Goenka L, Ramamoorthy T, Sharma M, Dhandapani VE, George M. Prognostic role of soluble ST2 in acute coronary syndrome with diabetes. Eur J Clin Invest. 2018;48(9) | |
| Goenka L, Padmanaban R, George M. The Ascent of Mineralocorticoid Receptor Antagonists in Diabetic Nephropathy. Curr Clin Pharmacol. 2019;14(2):78-83. | |
| Schwartz GG, Steg PG, Szarek M, Bhatt DL, Bittner VA, Diaz R. ODYSSEY OUTCOMES Committees and Investigators. Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome. N Engl J Med. 2018 Nov 29;379(22):2097-107. | |
| Goenka L, Jha D, Sharma M, Dhandapani VE, George M. Factors which influence the levels of ST-2, Galectin-3 and MMP-9 in acute coronary syndrome. Cardiovasc Hematol Disord Drug Targets. 2020;20(1):64-73. | 2019 |
| Goenka L, Rajendran S, Arumugam K, Rani J, George M. The assessment of the quality of randomized controlled trials published in Indian medical journals. Perspect Clin Res. 2019;10(2):79-83. | |
| Raj V, Charles S, Ramasamy M, Goenka L, Kamatchi M, George M, Arockiaraj J, Dhandapani VE , Narayanasamy A, Mala K. Cell cycle arrest in peripheral blood mononuclear cells: A non-invasive method for diagnosis of coronary artery disease. Process Biochem. 2019;84:153-60. | |
| Munusamy V, Goenka L, Sharma M, Ramamoorthy T, Jha D, Solaipriya S, Dhandapani, VE, George M. Clinical presentation and 2-year mortality outcomes in acute heart failure in a tertiary care hospital in South India: A retrospective cohort study. J Clin Prev Cardiol . 2019;8(2):56-63. | |
| Sen M, Goenka L, Jha D, Raj V, Charles S, Mala K, George M. The utility of plasma transthyretin and antioxidants as a biomarker of early pregnancy loss - a pilot study. ObsGyne Review: Journal of Obstetric and Gynecology. 2019;5(1):64-70. | |
| Vengatesh M, Jha D, Goenka L, Dhandapani VE, George M. The prognostic value of total antioxidant capacity in patients with acute coronary syndrome. J Cardiovasc Med Surg. 2019;5:75-84. | |
| Sen M, Samal S, Datta S, George M. Abnormal cardiotocographic findings and perinatal outcome: a prospective study. Int J Reprod Contracep Obstet Gynecol. 2019;8:4261. | |
| Goenka L, Uppugunduri Satyanarayana CR, S SK, George M. Neuroprotective agents in Acute Ischemic Stroke-A Reality Check. Biomed Pharmacother. 2019. | |
| Nanda RA, George M. Prevalence of duodenal ulcer and associated Helicobacter pylori infection in chronic liver disease. International Journal of Research in Medical Sciences. 2020;8(12);4442-6. | 2020 |
| Das A, George M, Jha D, Goenka L. Long term prognostic utility of matrix metalloproteinase-9 in patients with acute coronary syndrome - a systematic review. Curr Pharm Biotechnol. 2021;22(11):1482-9. | |
| Thangavel Mahalingam V, Kaliappan I, Rajappan Chandra SK, George M, Ramasamy MK, Sabarathinam S, Govind Prasad D. Clinical Pharmacokinetic Drug Interaction Potential of MenoAct851 in Adult, Female Healthy Volunteers. Curr Ther Res Clin Exp. 2020;Dec 8;94:100619. | |
| Yusuf S, Joseph P, Dans A, Gao P, Teo K, Xavier D, López-Jaramillo P, Yusoff K, | |
| Santoso A, Gamra H, Talukder S, Christou C, Girish P, Yeates K, Xavier F, Dagenais G, | |
| Rocha C, McCready T, Tyrwhitt J, Bosch J, Pais P; International Polycap Study 3 | |
| Investigators. Polypill with or without Aspirin in Persons without Cardiovascular | |
| Disease. N Engl J Med. 2021 Jan 21;384(3):216-28. | |
| George M, Goenka L. Alirocumab in Post ACS Patients - Saving Lives at a Premium. Curr Cardiol Rev. 2022;18(1) | 2021 |
| Raj JP, Venkatachalam S, Amaravati RS, Siby N, Oommen AM, Jose JE, George M, Ramraj B, Penumutsa VS, Bodda DR, Rajad R, Reshmi R, Inbaraj LR, Rajiv S, Bhandare B, Aiyappan R, Mathew P, Saleem AK, Shetty R, Bhuvaneswari G, Suresh Kumar T, Prasanna BL, Manderwad GP. Extent of awareness and attitudes on plagiarism among post-graduate resident doctors and junior medical faculty in India: a cross-sectional, multicentric study. BMJ Open. 2021;11(6):e046904. | |
| Meenakumari R, Thangaraj K, Sundaram A, Sundaram MM, Shanmugapriya P, Mariappan A, George M, Suba V, Rajalakshmi E, Sendhilkumar M. Clinical outcomes among COVID-19 patients managed with modern and traditional Siddha medicine - A retrospective cohort study. J Ayurveda Integr Med. 2022;13(2):100470. | |
| Howard C, Sheridan J, Picca L, Reza S, Smith T, Ponnapalli A, Calow R, Cross O, Iddawela S, George M, Livra Dias D, Srinivasan A, Munir W, Bashir M, Idhrees M. TEVAR for complicated and uncomplicated type B aortic dissection-Systematic review and meta-analysis. J Card Surg. 2021;36(10):3820-30. | |
| Mohan VK, George M. A Review of the contribution of gut-dependent microbiota derived marker, Trimethylamine N-oxide (TMAO) in coronary artery disease. Curr Res Nutr Food Sci. 2021; 9(3). | |
| Rakshit S, Sunny JS, George M, Hanna LE, Sarkar K. R-loop modulated epigenetic regulation in T helper cells mechanistically associates coronary artery disease and non-small cell lung cancer. Transl Oncol. 2021;14(10):101189. | |
| Roy AG, Ghosh A, Sinha K, Mitra B, Rakshit S, George M, Sarkar K. Diospyros peregrina fruit preparation mediated immunomodulation of lymphocytes isolated from the blood of breast cancer patients. Iran J Immunol. 2021;18(2):111-8. | |
| Raj V, Charles S, Goenka L, et al. Assessment of peripheral blood mononuclear cells senescence and endothelial dysfunction among adults with high cardiovascular risk. Arq Bras Cardiol. 2021;116(1):37-47. | |
| Selvarajan S, Anandaradje A, Shivabasappa S, MelepurakkalSadanandan D, Nair NS, George M. Efficacy of pharmacological interventions in COVID-19: A network meta-analysis. Br J Clin Pharmacol. 2022;88(9):4080-91. | 2022 |
| Raj JP, Venkatachalam S, Amaravati RS, Baburajan R, Oommen AM, Jose JE, R R, R R, George M, Ramraj B, Gopalakrishnan B, Kumar TS, Saleem AK, Rai M, Penumutsa VS, Bodda DR, Prasanna BL, Manderwad GP, S R, Bhandare B, Mada P, Mathai D, Aiyappan R, Mathew P. Extent of knowledge and attitudes on plagiarism among undergraduate medical students in South India - a multicentre, cross-sectional study to determine the need for incorporating research ethics in medical undergraduate curriculum. BMC Med Educ. 2022;22(1):380. | |
| Rakshit S, Sunny JS, George M, Hanna LE, Leela KV, Sarkar K. T helper cell-mediated epitranscriptomic regulation via m6A RNA methylation bridges link between coronary artery disease and invasive ductal carcinoma. J Cancer Res Clin Oncol. 2022;148(12):3421-36. | |
| Idhrees M, Narayan P, George M, Radhakrishna P, Abraham SJ, Velayudhan B. The motivators and barriers to a career in cardiothoracic surgery: a cross-sectional study among surgical residents in India. Indian J Thorac Cardiovasc Surg. 2022;38(6):613-23. | |
| Pal R, Rakshit S, Shanmugam G, et al. Pal R, Rakshit S, Shanmugam G, Paul N, Bhattacharya D, Chatterjee A, Singh A, George M, Sarkar K. Immunobiology. 2022;227(5):152259. | |
| Shanmugam G, Sunny JS, Rakshit S, George M, Leela KV, Sarkar K. Involvement of inflammatory cytokines and epigenetic modification of the mtTFA complex in T-helper cells of patients suffering from non-small cell lung cancer and chronic obstructive pulmonary disease. Mol Immunol. 2022;151:70-83. | |
| Kaushik RR,Koranne M, Rao MS, Rakshit S, Shanmugam G, George M, Sarkar K, Role of Diospyros peregrina fruit preparation in suppressing regulatory T (Treg) cells in the tumor microenvironment of breast and lung cancer. Phytomed Plus. 2022;2(4). | |
| Rathinam KK, Abraham JJ, S HP, S A S, Sen M, George M, A P. Evaluation of pharmacological interventions in the management of adenomyosis: a systematic review. Eur J Clin Pharmacol. 2022 Apr;78(4):531-45. | |
| Bhattacharjee S, George M, Shim YB, Bernaurdshaw N, Das J. Electropotential-Inspired star-shaped gold nanoconfined multiwalled carbon nanotubes: a proof-of-concept electrosensoring interface for lung metastasis biomarkers. ACS Appl Bio Mater. 2022;5(12):5567-81. | |
| Aryal A, Vandana VG, Meghana CV, Himaja D, Sandeep D, Sarumathy S, George M, Roopini R. Anti mullerian hormone and antral follicle count for prediction of ovarian reserve in female infertile patients: A cross sectional study. Int J Health Sci. 2022;III:1673-83. | |
| Ella R, Reddy S, Blackwelder W, Potdar V, Yadav P, Sarangi V, Aileni VK, Kanungo S, Rai S, Reddy P, Verma S, Singh C, Redkar S, Mohapatra S, Pandey A, Ranganadin P, Gumashta R, Multani M, Mohammad S, Bhatt P, Kumari L, Sapkal G, Gupta N, Abraham P, Panda S, Prasad S, Bhargava B, Ella K, Vadrevu KM; COVAXIN Study Group. Efficacy, safety, and lot-to-lot immunogenicity of an inactivated SARS-CoV-2 vaccine (BBV152): interim results of a randomised, double-blind, controlled, phase 3 trial. Lancet. 2021 Dec 11;398(10317):2173-84. | |
| Eikelboom JW, Jolly SS, Belley-Cote EP, Whitlock RP, Rangarajan S, Xu L, Heenan L, Bangdiwala SI, Tarhuni WM, Hassany M, Kontsevaya A, Harper W, Sharma SK, Lopez-Jaramillo P, Dans AL, Palileo-Villanueva LM, Avezum A, Pais P, Xavier D, Felix C, Yusufali A, Lopes RD, Berwanger O, Ali Z, Wasserman S, Anand SS, Bosch J, Choudhri S, Farkouh ME, Loeb M, Yusuf S. Colchicine and aspirin in community patients with COVID-19 (ACT): an open-label, factorial, randomised, controlled trial. Lancet Respir Med. 2022 Dec;10(12):1160-8. | |
| Rathinam KK, Abraham JJ, Karuppaiah H, Selvaraj HP, Samal S, George M. Evaluation of endpoints used in clinical trials on adenomyosis - A Systematic Review. Rev Recent Clin Trials. 2023;18(2):83-91. | 2023 |
| Bhootra S, Jill N, Rajak R, Shanmugam G, Rakshit S, Kannanthodi S, Thakkar V, George M, Sarkar K. Diospyros malabarica fruit preparation mediates immunotherapeutic modulation and epigenetic regulation to evoke protection against non-small cell lung cancer (NSCLC). J Ethnopharmacol. 2023;314:116525 | |
| Chandnani N, Choudhari VS, Talukdar R, Rakshit S, Shanmugam G, Guchait S, Gupta I, George M, Sarkar K. Depletion of enhancer zeste homolog 2 (EZH2) directs transcription factors associated with T cell differentiation through epigenetic regulation of Yin Yang 1(YY1) in combating non-small cell lung cancer (NSCLC). Med Oncol. 2023;40(7):185. | |
| George M, Balachandran K, Jinson J. Fathoming the Role of Semaglutide in Obesity Therapeutics. Clin Ther. 2023;45(8):804-5. | |
| Shanmugam G, Subramaniyam K, George M, Sarkar K. HDAC inhibition regulates oxidative stress in CD4+Thelper cells of chronic obstructive pulmonary disease and non-small cell lung cancer patients via mitochondrial transcription factor a (mtTFA) modulating NF-κB/HIF1α axis. Int Immunopharmacol. 2023. | |
| Mahalakshmi Surendran A, Rai A, Rakshit S, George M, Sarkar K. Immunomodulatory Role of Diospyros peregrina Fruit Preparation in Breast Cancer by Utilizing Macrophage Mediated Antigen Presentation and T Helper Cell (Th) Differentiation. Clin Breast Cancer. 2023;23(3) | |
| Samal S, Manoharan K, Jinson J, George M, Rao AA. Prediction of maternal and foetal outcomes among patients with preeclampsia using circulatory biomarkers (MMP-9 & ST2) - A prospective cohort study. Placenta. 2023;142:12-7. | |
| Manoharan K; Jinson J; Ramesh K; George M. Clinical trial trends over the last 5 years among the BRICS (Brazil, Russia, India, China, and South Africa) nations. Perspectives in Clinical Research. October 27, 2023. | |
| Chandnani N, Mandal A, Gupta I, Mukherjee O, Rakshit S, Shanmugam G, George M, Sarkar K. Association of Wiskott-Aldrich syndrome protein (WASp) in epigenetic regulation of B cell differentiation in non-small-cell lung cancer (NSCLC). Med Oncol. 2023;41(1):28. | |
| Mukherjee O, Paul S, Das S, Rakshit S, Shanmugam G, George M, Sarkar K. Doxorubicin induced epigenetic regulation of dendritic cell maturation in association with T cell activation facilitates tumor protective immune response in non-small cell lung cancer (NSCLC). Pathol Res Pract. 2024;253 |
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